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Regenerative Medicine

Regenerative medicine is a scientific and medical discipline which focuses on reining the power of stem cells and the regenerative capacity of the body in order to restore the functioning of damaged cells, tissues and organs. The goal of regenerative medicine is to find the path to cure previously untreated injuries and diseases.

Stem cells are present in all of us acting like a repair system for the body. However, with increased age sometimes we don’t get optimum stem cells to the injured area. Regenerative medicine functions to amplify the natural repair system of the patient’s body.

To obtain the stem cells, your doctor administers a local anesthetic to the back of the hip (Posterior superior iliac spine) and takes a small bone marrow sample through a needle. The sampling procedure is called bone marrow aspirate, which is different from bone marrow biopsy and is less painful. Blood is also taken from a vein of the patient’s arm. These sample cells are processed and then re-injected into the area where repair of the damaged tissue is required. Imaging guidance such as real-time fluoroscopy or musculoskeletal ultrasound is used along with MRI to plan the location of the injection.

Mesenchymal stem cells (MSCs) are multipotent cells derived from non-marrow tissues, such as umbilical cord blood, adipose tissue, adult muscle or dental pulp of deciduous baby teeth. The isolated MSCs are also injected on the same day, along with natural growth factors obtained from the blood platelets of the patient. The main objective is to deliver a much greater number of stem cells to the injured area to restore its function.

Researchers are employing different approaches for creating new pluripotent stem cell lines, such as in vitro fertilization embryos, nuclear transfer, and induced pluripotent stem (iPS). Different government and private organizations are committed to developing new stem cell-based therapies for chronic, debilitating diseases.

Pluripotent stem cells hold the greatest potential to treat a wide range of diseases but to create new stem cell therapies takes a long time. Before testing pluripotent stem cells in human disease, researchers must grow the right cell type, ie. differentiation of stem cells, and then their safety is first tested in animals before moving to human trials.  

Regenerative medicine has a great potential to cure injured and impaired tissues. Scientists all over the world are researching ways to rein stem cells and use them for diagnosing and treating various disease conditions. 

Some risks factors are associated with regenerative medicine and include immune reactions from injected stem cells and also cells may become contaminated with bacteria, viruses or other pathogens that may cause disease. The procedure to either remove or inject the cells also has the risk of introducing an infection to the damaged tissue into which they are injected.

In some cases, certain complications such as formation of tumors can be seen as a result of unproven stem cell treatment.

Why Regenerative Medicine

Regenerative medicine-based therapy is increasingly being recommended in the management of various orthopaedic conditions due to its diverse benefits listed below.

  • It uses natural components of your body tissues, thus reducing the risk of adverse reactions or infection.
  • In addition to regenerating tissues, it also provides pain relief.
  • Certain degenerative conditions and injuries which were previously only treated by surgery may now show significant improvement with regenerative medicine, delaying or altogether avoiding the need for surgery. This is particularly beneficial for the aged and those with health conditions in whom surgery is not recommended.
  • In combination with surgery, it enhances healing and recovery.
  • Regenerative medicine procedures take no more than 2 hours and you can return to your activities in a day or two, making it ideal for sports professionals and those who do not wish to be disabled by a surgical procedure and a long recovery period.
  • The effects of treatment are usually long lasting and may be repeated if necessary.

Regenerative Orthopaedics

Regenerative orthopaedics is a subspecialty of regenerative medicine that focuses on regeneration of lost tissue, acceleration of healing, and pain relief to treat orthopaedic conditions such as osteoarthritis, tendonitis, low back pain, joint injuries, ligament injuries, sprains and strains etc. Regenerative orthopaedics uses:

  • Stem cells: Undifferentiated cells that can transform into any type of tissue. These are usually obtained from the bone marrow or fat.
  • Platelets: Platelets obtained from blood that help activate stem cells
  • Growth factors: Proteins obtained from blood that are essential for tissue repair and regeneration

Some of the conditions that can be treated with regenerative orthopaedics include many common conditions such as osteoarthritis (degenerative arthritis), low back pain, strains and sprains, nerve injuries, and tendon and ligament tears.

Regenerative orthopaedics is used to avoid or delay surgery, accelerate healing after surgery or injury, or when surgery or other therapies have failed. Recovery after treatment is quick and you may return to normal activities in 72 hours and to sports in 2 weeks.

American Academy of Orthopaedic Surgeons American Orthopaedic Society for Sports Medicine Arthroscopy Association of North America American Shoulder and Elbow Surgeons Ruth Jackson Orthopaedic Society Orthopaedic Research Society University of Colorado Western Orthopaedic Association Official Website of University of Denver Athletics Rapid Youth Score Club